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In some embodiments, cosolvents are used to enhance drug solubility

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& Wigley, D

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In certain embodiments, the preparations optionally contain a suitable buffering system, such as phosphate, citrate, borate, tris, etc., and pH regulators such as sodium hydroxide and hydrochloric acid also are optionally used in the formulations of the disclosures

Along with the beneficial effect noted with fundoscopy assessment, all BPC 157 rats (both g- and ng-regimen, those that received medication at 20 min after L-NAME, and those that received medication at 48 h after L-NAME) commonly presented preserved plexiform and inner nuclear layer and retinal thickness (Figure 6, Figure 7)